ChemicalBook > CAS DataBase List > (S)-1-N-Boc-2-methylpiperazine

(S)-1-N-Boc-2-methylpiperazine

Product Name
(S)-1-N-Boc-2-methylpiperazine
CAS No.
169447-70-5
Chemical Name
(S)-1-N-Boc-2-methylpiperazine
Synonyms
tert-butyl (S)-2-methylpiperazine-1-carboxylate;(R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-1-Boc-2-methl-piperazine;(S)-N-Boc-2-methylpiperazine;(R)-2-METHYL-1-BOC-PIPERAZINE;1-Boc-2-(S)-Methyl Piperazine;(S)-1-Boc-2-methyl-piperazine;(S)-N1-BOC-2-METHYLPIPERAZINE;(S)-1-N-BOC-2-METHYL PIPERAZINE
CBNumber
CB9714476
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
169447-70-5.mol
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(S)-1-N-Boc-2-methylpiperazine Property

Melting point:
43.0 to 47.0 °C
Boiling point:
268.7±15.0 °C(Predicted)
Density 
0.997±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
8.49±0.40(Predicted)
color 
White to Almost white
InChI
InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
InChIKey
DATRVIMZZZVHMP-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C
CAS DataBase Reference
169447-70-5(CAS DataBase Reference)
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Safety

RIDADR 
UN3077
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4846
Product name
(S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
B4846
Product name
(S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$258
Updated
2024/03/01
TRC
Product number
B656975
Product name
(S)-1-Boc-2-methylpiperazine
Packaging
10g
Price
$970
Updated
2021/12/16
Activate Scientific
Product number
AS3110
Product name
(S)-1-Boc-2-methylpiperazine
Purity
97+% ee
Packaging
250g
Price
$1480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0040694
Product name
(S)-1-N-BOC-2-METHYLPIPERAZINE
Purity
95.00%
Packaging
10G
Price
$2055.9
Updated
2021/12/16
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(S)-1-N-Boc-2-methylpiperazine Chemical Properties,Usage,Production

Uses

(S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Synthesis

A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification.

(S)-1-N-Boc-2-methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-N-Boc-2-methylpiperazine Suppliers

Americas 1 Canada 1 China 193 Europe 3 Germany 3 India 3 Japan 2 United Kingdom 13 United States 38 Global 257
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6027
Advantage
65
Accela ChemBio Inc.
Tel
(+1)-858-699-3322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
19965
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from (S)-1-N-Boc-2-methylpiperazine manufacturers

Shanghai UCHEM Inc.
Product
(S)-1-N-Boc-2-methylpiperazine 169447-70-5
Price
US $73.00-607.00/g
Min. Order
25g
Purity
0.99
Supply Ability
10
Release date
2023-12-18
Career Henan Chemical Co
Product
(S)-1-N-Boc-2-methylpiperazine 169447-70-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08

169447-70-5, (S)-1-N-Boc-2-methylpiperazineRelated Search:

tert-Butyl peroxybenzoate 1-Methylpiperazine N-Methyl-2-pyrrolidone 1,2-Dimethylhydrazine Dihydrochloride N-Methylolacrylamide 2-Methylpiperazine Diisobutyl phthalate 1-BENZHYDRYLPIPERAZINE Butylparaben 1-Methylimidazole N-Methyldiethanolamine N-Methylacetamide Isobutyl chloroformate (S)-1-Boc-2-isopropylpiperazine (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER D-1-N-Boc-prolinamide (S)-(+)-N-TBOC-2-METHYLPIPERIDINE (S)-tert-butyl 4-aMinoazepane-1-carboxylate

  • 1-Boc-2-(S)-Methyl Piperazine
  • TERT-BUTYL (2S)-2-METHYPIPERAZINE-1-CARBOXYLATE
  • (R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (R)-2-METHYL-1-BOC-PIPERAZINE
  • (S)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE
  • (S)-1-N-BOC-2-METHYL PIPERAZINE
  • (S)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE
  • (S)-1-Boc-2-methyl-piperazine
  • Tert-Butyl2(S)-methylpiperazine-1-carboxylate
  • 2-S-Methyl-piperazine-1-carboxylic acid tert-butyl ester
  • (S)-1-N-Boc-2-Methylpiperizine tert-butyl 2(S)-methylpiperazine-1-carboxylate
  • (S)-N1-BOC-2-METHYLPIPERAZINE
  • (S)-1-Boc-2-methl-piperazine
  • (S)-1-N-Boc-2-Methylpiperazine ,98%
  • (2S)-2-Methylpiperazine, N1-BOC protected 98%
  • tert-Butyl (2S)-2-methylpiperazine-1-carboxylate (2S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine
  • (2S)-2-Methyl-1-piperazinecarboxylic Acid 1,1-DiMethylethyl Ester
  • tert-Butyl (2S)-2-Methylpiperazine-1-carboxylate
  • 1-Piperazinecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)-
  • (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine
  • tert-butyl (S)-2-methylpiperazine-1-carboxylate
  • (2S)-2-Methylpiperazine,N1-BOCprotected98%
  • (S)-N-Boc-2-methylpiperazine
  • (S)-N-Boc-2-methylpiperazine,98%e.e.
  • (<i>S</i>)-1-(<i>tert</i>-Butoxycarbonyl)-2-methylpiperazine
  • (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine &gt
  • (S)-2-Methyl-1-piperazinecarboxylic Acid tert-Butyl Ester
  • tert-Butyl (S)-2-Methyl-1-piperazinecarboxylate
  • 169447-70-5
  • 170033-47-4
  • Chiral Reagents
  • Heterocycles
  • pharmacetical
  • Piperaizine